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Results for "

immunosuppressive activities

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adenosine Receptor (1) Antibiotic (1) Antifolate (1) Apoptosis (13) Aryl Hydrocarbon Receptor (2) Autophagy (4) Bacterial (2) Calcium Channel (1) Dihydroorotate Dehydrogenase (1) DNA Alkylator/Crosslinker (2) DNA/RNA Synthesis (2) EGFR (1) Endogenous Metabolite (1) Ferroptosis (1) FKBP (4) Fungal (1) Glucocorticoid Receptor (7) Glucosidase (1) HBV (2) HDAC (1) Isotope-Labeled Compounds (6) mTOR (3) NO Synthase (1) Parasite (1) PD-1/PD-L1 (1) Phosphatase (1) PKC (1) Potassium Channel (1) SHP2 (1) Tim3 (1)
By Research Areas:	Cancer (23) Endocrinology (7) Infection (4) Inflammation/Immunology (28) Metabolic Disease (1) Neurological Disease (2)

By Targets:

Adenosine Receptor (1)

Antibiotic (1)

Antifolate (1)

Apoptosis (13)

Aryl Hydrocarbon Receptor (2)

Autophagy (4)

Bacterial (2)

Calcium Channel (1)

Dihydroorotate Dehydrogenase (1)

DNA Alkylator/Crosslinker (2)

DNA/RNA Synthesis (2)

EGFR (1)

Endogenous Metabolite (1)

Ferroptosis (1)

FKBP (4)

Fungal (1)

Glucocorticoid Receptor (7)

Glucosidase (1)

HBV (2)

HDAC (1)

Isotope-Labeled Compounds (6)

mTOR (3)

NO Synthase (1)

Parasite (1)

PD-1/PD-L1 (1)

Phosphatase (1)

PKC (1)

Potassium Channel (1)

SHP2 (1)

Tim3 (1)

By Research Areas:

Cancer (23)

Endocrinology (7)

Infection (4)

Inflammation/Immunology (28)

Metabolic Disease (1)

Neurological Disease (2)

Inhibitors & Agonists

Screening Libraries

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W012352

2-Hydroxyanthraquinone

Others Cancer

2-Hydroxyanthraquinone, a natural compound, possesses antitumor and immunosuppressive activity .

2-Hydroxyanthraquinone	Others	Cancer
2-Hydroxyanthraquinone, a natural compound, possesses antitumor and immunosuppressive activity .

HY-17420A

Cyclophosphamide hydrate 20+ Cited Publications Cyclophosphamide monohydrate	DNA Alkylator/Crosslinker	Cancer
Cyclophosphamide hydrate is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities.

HY-161255

3,4-DAA	NO Synthase	Inflammation/Immunology
3,4-DAA is an orally active Anthranilic acid derivative with potent immunosuppressive activities. 3, 4-DAA can alleviate the severity of colitis through inhibiting Th1 cells response, promoting Th2 cytokines expression and inducing CD4 ⁺CD25 ⁺ T cells expression . 3,4-DAA suppressed expression of inducible nitric oxide synthase (iNOS) and nitric oxide (NO) release from EOC20 cells induced by IFN-γ and Lipopolysaccharide .

HY-N4319

Jasminoside B

Others Inflammation/Immunology

Jasminoside B is a natural compound with immunosuppressive activity .
HY-N10238

Mycestericin G

Endogenous Metabolite Inflammation/Immunology

Mycestericin G is a sphingosine-like fungal metabolite that exhibits immunosuppressive activity .
HY-N12739

Sibiriquinone A

Others Others

Sibiriquinone A is a diterpene with immunosuppressive activity that can be isolated from the aerial parts of Veronicastrum sibiricum. Sibiriquinone A .

Jasminoside B	Others	Inflammation/Immunology
Jasminoside B is a natural compound with immunosuppressive activity .

Mycestericin G	Endogenous Metabolite	Inflammation/Immunology
Mycestericin G is a sphingosine-like fungal metabolite that exhibits immunosuppressive activity .

Sibiriquinone A	Others	Others
Sibiriquinone A is a diterpene with immunosuppressive activity that can be isolated from the aerial parts of Veronicastrum sibiricum. Sibiriquinone A .

HY-10218S

Everolimus-d4 RAD001-d₄; SDZ-RAD-d₄	mTOR FKBP Autophagy Apoptosis	Cancer
Everolimus-d₄ is the deuterium labeled Everolimus. Everolimus (RAD001) is a Rapamycin derivative and a potent, selective and orally active mTOR1 inhibitor. Everolimus binds to FKBP-12 to generate an immunosuppressive complex. Everolimus inhibits tumor cells proliferation and induces cell apoptosis and autophagy. Everolimus has potent immunosuppressive and anticancer activities[1][2].

HY-10218

Everolimus Maximum Cited Publications 73 Publications Verification RAD001; SDZ-RAD	mTOR FKBP Autophagy Apoptosis Bacterial	Cancer
Everolimus (RAD001) is a Rapamycin (HY-10219) derivative and a potent, selective and orally active mTOR1 inhibitor. Everolimus binds to FKBP-12 to generate an immunosuppressive complex. Everolimus inhibits tumor cells proliferation and induces cell apoptosis and autophagy. Everolimus has potent immunosuppressive and anticancer activities .

HY-19317

ITE 5+ Cited Publications	Aryl Hydrocarbon Receptor	Inflammation/Immunology Cancer
ITE is a potent endogenous agonist of aryl hydrocarbon receptor (AhR), binding directly to AHR, with a K_i of 3 nM. ITE also has immunosuppressive activity.

HY-17420AS

Cyclophosphamide-d8 hydrate	Isotope-Labeled Compounds DNA Alkylator/Crosslinker	Cancer
Cyclophosphamide-d₈ (hydrate) is the deuterium labeled Cyclophosphamide hydrate. Cyclophosphamide hydrate is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities[1][2].

HY-13570

Betamethasone 1 Publications Verification	Glucocorticoid Receptor Apoptosis	Inflammation/Immunology Endocrinology Cancer
Betamethasone is a synthetic glucocorticoid with anti-inflammatory and immunosuppressive activities. Betamethasone accelerates fetal lung maturation and induces gene expression and apoptosis .

HY-13570A

Betamethasone hydrochloride	Glucocorticoid Receptor Apoptosis	Inflammation/Immunology Endocrinology
Betamethasone hydrochloride is a synthetic glucocorticoid with anti-inflammatory and immunosuppressive activities. Betamethasone hydrochloride accelerates fetal lung maturation and induces gene expression and apoptosis .

HY-10218R

Everolimus (Standard) RAD001 (Standard); SDZ-RAD (Standard)	mTOR FKBP Autophagy Apoptosis Bacterial	Cancer
Everolimus (Standard) is the analytical standard of Everolimus. This product is intended for research and analytical applications. Everolimus (RAD001) is a Rapamycin (HY-10219) derivative and a potent, selective and orally active mTOR1 inhibitor. Everolimus binds to FKBP-12 to generate an immunosuppressive complex. Everolimus inhibits tumor cells proliferation and induces cell apoptosis and autophagy. Everolimus has potent immunosuppressive and anticancer activities .

HY-16035

Alatrofloxacin	DNA/RNA Synthesis Antibiotic	Cancer
Alatrofloxacin, the parenteral proagent of Trovafloxacin, is a fluoronaphthyridone which contains an L-alanyl-L-alanyl salt. Alatrofloxacin functions similar to other fluoroquinolone antibiotics in that it not only has antibiotic activity to kill invading organisms by interfering with DNA synthesis, it possesses immunosuppressive activity .

HY-13570S

Betamethasone-d5	Isotope-Labeled Compounds Glucocorticoid Receptor Apoptosis	Inflammation/Immunology Endocrinology Cancer
Betamethasone-d₅ is the deuterium labeled Betamethasone. Betamethasone is a synthetic glucocorticoid with anti-inflammatory and immunosuppressive activities. Betamethasone accelerates fetal lung maturation and induces gene expression and apoptosis[1][2][3][4].

HY-N11015

Withaphysalin R	Others	Infection Inflammation/Immunology Cancer
Withaphysalin R (compound 5) is a Withanolide that can be isolated from the Solanaceae. Withanolide is a steroid ester with an ergosterol skeleton, and some of these compounds have some significant activities, including cytotoxic and immunosuppressive, antitumor, anti-inflammatory, anticonvulsive, and antioxidant .

HY-118438

10-Cl-BBQ	Aryl Hydrocarbon Receptor	Inflammation/Immunology
10-Cl-BBQ is a high affinity AhR ligand with immunosuppressive activity. 10-Cl-BBQ promotes cytosol to nuclear translocation of AhR and activates the AhR-regulated reporter gene at nanomolar concentrations .

HY-N7766

Rubropunctatin	Apoptosis	Inflammation/Immunology Cancer
Rubropunctatin, an orange azaphilone pigment, is isolated from the extracts of Monascus pilosus-fermented rice (red-mold rice). Rubropunctatin has anti-inflammatory, immunosuppressive and antioxidative effects, and also exhibits anti-tumor activity .

HY-13570S1

Betamethasone-d5-1	Isotope-Labeled Compounds Glucocorticoid Receptor Apoptosis	Inflammation/Immunology Endocrinology Cancer
Betamethasone-d₅-1 is deuterium labeled Betamethasone. Betamethasone is a synthetic glucocorticoid with anti-inflammatory and immunosuppressive activities. Betamethasone accelerates fetal lung maturation and induces gene expression and apoptosis[1][2][3][4].

HY-W751099

Corticosterone-13C3	Isotope-Labeled Compounds	Others
Corticosterone- ¹³C₃ is a ¹³C-labeled corticosterone (HY-B1618). Corticosterone (17-Deoxycortisol) is an orally available glucocorticoid that can regulate limbic system neurons and has good immunosuppressive activity.

HY-135670

Glycosidase-IN-1	Glucosidase	Metabolic Disease
Glycosidase-IN-1 (Compound 9) is a glycosidase inhibitor synthesized from D-mannose. Glycosidase-IN-1 be used to synthesize some immunosuppressive agents and β-glucosidase inhibitors. Glycosidase-IN-1 has hypoglycemic activity .

HY-13570R

Betamethasone (Standard)	Glucocorticoid Receptor Apoptosis	Inflammation/Immunology Endocrinology Cancer
Betamethasone (Standard) is the analytical standard of Betamethasone. This product is intended for research and analytical applications. Betamethasone is a synthetic glucocorticoid with anti-inflammatory and immunosuppressive activities. Betamethasone accelerates fetal lung maturation and induces gene expression and apoptosis .

HY-N6961

Lapachol 1 Publications Verification	Dihydroorotate Dehydrogenase DNA/RNA Synthesis Parasite	Infection Inflammation/Immunology Cancer
Lapachol, a natural naphthoquinone, is an orally active, potent DHODH inhibitor. Lapachol has immunosuppressive activity on lymphocytes through its direct ability to block DHODH activity and inhibit pyrimidine synthesis. Lapachol is a vitamin K antagonist with antitumor activity and can inhibit DNA and RNA synthesis in neoplastic cells. Lapachol has anti-Leishmania activity .

HY-13571AS1

Beclometasone dipropionate-d10	Isotope-Labeled Compounds Glucocorticoid Receptor	Inflammation/Immunology Endocrinology
Beclometasone dipropionate-d₁₀ is the deuterium labeled Beclometasone dipropionate. Betamethasone dipropionate, the proagent of Betamethasone, is an orally active and potent glucocorticoid with anti-inflammatory and immunosuppressive activity. Betamethasone appears to be an effective inhibitor of LPS-induced inflammation and MMP release[1][2].

HY-P3410

Trichomide A	SHP2 Phosphatase	Inflammation/Immunology
Trichomide A is a potent activator of SHP2. Trichomide A is a natural cyclodepsipeptide. Trichomide A displays immunosuppressive activity against activated T lymphocyte–mediated immune responses in Con A-activated T cells. Trichomide A have the potential for the research of immune-related skin diseases .

HY-13571AS

Beclometasone dipropionate-d6	Isotope-Labeled Compounds Glucocorticoid Receptor	Inflammation/Immunology Endocrinology
Beclometasone dipropionate-d₆ is deuterium labeled Beclometasone dipropionate. Betamethasone dipropionate, the proagent of Betamethasone, is an orally active and potent glucocorticoid with anti-inflammatory and immunosuppressive activity. Betamethasone appears to be an effective inhibitor of LPS-induced inflammation and MMP release[1][2].

HY-108583

Psora-4 5-(4-Phenylbutoxy)psoralen	Potassium Channel	Inflammation/Immunology
Psora-4 is a potent and selective inhibitor of K_v1.3 (voltage-gated potassium channels) with an EC₅₀ of 3 nM . Psora-4 has immunosuppressive activity and inhibits proliferation of human and rat myelin-specific effector memory T cells in vitro .

HY-14518

Aminopterin 4-Aminofolic acid; APGA	Antifolate	Inflammation/Immunology Cancer
Aminopterin (4-Aminofolic acid), the 4-amino derivative of folic acid, is a folic acid antagonist. Aminopterin catalyses the reduction of folic acid to tetrahydrofolic acid, and competitively inhibits dihydrofolate reductase (DHFR) with a K_i of 3.7 pM. Aminopterin has anticancer and immunosuppressive activity. Aminopterin is used in treatment of pediatric leukemia .

HY-N6939

Pseudolaric Acid B 1 Publications Verification	HBV Fungal Apoptosis Autophagy Ferroptosis	Infection Inflammation/Immunology Cancer
Pseudolaric Acid B is a diterpene isolated from the root of Pseudolarix kaempferi (pinaceae), has anti-cancer, antifungal, and antifertile activities, and shows immunosuppressive activity on T lymphocytes . Pseudolaric Acid B inhibits hepatitis B virus (HBV) secretion through apoptosis and cell cycle arrest. Pseudolaric Acid B induces autophagy .

HY-N7119

Cimicifugoside	Others	Inflammation/Immunology
Cimicifugoside, a triterpenoid isolated from Cimicifuga simplex, is a novel specific nucleoside transport inhibitor that displays synergistic potentiation of methotrexate cytotoxicity . Cimicifugoside shows immunosuppressive activity, which is preferentially directed toward B-cell function with larger doses being required for suppression of T-cell function .

HY-N0854

Alisol F	HBV	Infection
Alisol F is a triterpene isolated from Alisma orinentale, has immunosuppressive and anti-virus functions. Alisol F exhibits inhibitory activity in vitro on hepatitis B virus (HBV) surface antigen (HBsAg) secretion of the HepG2.2.15 cell line with an IC₅₀ of 0.6 μM .

HY-156520

Immunosuppressant-1	Apoptosis	Inflammation/Immunology
Immunosuppressant-1 (Compound 31) inhibits anti-CD3/anti-CD28 co-stimulated T-cell proliferation. Immunosuppressant-1 has immunosuppressive activity, and induces apoptosis by activating caspase-3 and PARP in activated lymph node cells .

HY-126147

J22352	HDAC	Cancer
J22352 is a PROTAC (proteolysis-targeting chimeras)-like and highly selective HDAC6 inhibitor with an IC₅₀ value of 4.7 nM. J22352 promotes HDAC6 degradation and induces anticancer effects by inhibiting autophagy and eliciting the antitumor immune response in glioblastoma cancers, and leading to the restoration of host antitumor activity by reducing the immunosuppressive activity of PD-L1 .

HY-106345

ILS-920	FKBP Calcium Channel	Neurological Disease Inflammation/Immunology
ILS-920 is a nonimmunosuppressive Rapamycin analog with reduced immunosuppressive activity and potent neuroprotective activity. ILS-920 binds selectively to the immunophilin FKBP52 and to the β1-subunit of L-type voltage-gated calcium channels (VGCC). ILS-920 shows 200-fold selectivity for FKBP52 versus FKBP12 .

HY-N0587

Demethylzeylasteral 2 Publications Verification	Apoptosis	Inflammation/Immunology Cancer
Demethylzeylasteral is a triterpene compound isolated from Tripterygium wilfordii Hook F, with anti-inflammatory, immunosuppressive and anti-tumor activities . Demethylzeylasteral can significantly alleviates atherosclerosis (AS) . Demethylzeylasteral inhibits triple-negative breast cancer invasion by blocking the canonical and non-canonical TGF-β signaling pathways .

HY-P99618

Fidasimtamab IBI-315; BH2950	EGFR PD-1/PD-L1	Inflammation/Immunology Cancer
Fidasimtamab (IBI-315; BH2950) is a recombinant human IgG1 bispecific antibody that targets, binds and inhibits both HER2 and PD-1 and their downstream signalling pathways, and links PD-1 expressing T cells to HER2 expressing tumour cells. Fidasimtamab has potential immunosuppressive and antitumor activity .

HY-18620

DZ2002 1 Publications Verification	Others	Inflammation/Immunology
DZ2002 is an orally active, reversible and low-cytotoxic type III SAHH inhibitor (K_i=17.9 nM), with good immunosuppressive activity. DZ2002 prevents the development of experimental dermal fibrosis by reversing the profibrotic phenotype of various cell types. DZ2002 can be used in studies of autoimmune diseases such as lupus syndrome and systemic sclerosis .

HY-A0183

Phosphatidylserine Phospholipids, phosphatidylserines; Serine glycerophosphatides
Phosphatidylserine is a conserved anti-inflammatory and immunosuppressive signal that is highly dysregulated in the tumor microenvironment and autoimmune diseases. During apoptosis and cellular stress，the related disrupting enzymes Xkr8 and TMEM16 mediate Phosphatidylserine externalization. Phosphatidylserine externalization produces a "eat me" signal that initiates endocytosis and helps clear the body of apoptotic cells. When pathogens use Phosphatidylserine and apoptotic mimicry to evade host immune responses，targeting Phosphatidylserine strategies can stimulate immune activity .

HY-155175

TIM-3-IN-2	Tim3	Cancer
TIM-3-IN-2 (Compound A-41) is a Tim3 inhibitor (K_D: 0.61 μM). TIM-3-IN-2 blocks TIM-3 interactions with PtdSer, CEACAM1, and Gal-9. TIM-3-IN-2 inhibits the immunosuppressive function of TIM-3. TIM-3-IN-2 reverses the TIM-3-mediated blockade of the production of proinflammatory cytokines, and maximizes the T-cell antitumor activity against AML cell lines .

HY-117720

OSU-2S	PKC Apoptosis	Cancer
OSU-2S is a potent PKCδ activator. OSU-2S inhibits cell proliferation and migration. OSU-2S decreases the expression of p-ERK1/2, increases the expression of PKCδ (38 kDa) when combined with Sorafenib (HY-10201). OSU-2S induces Apoptosis. OSU-2S slao is a non-immunosuppressive analogue of FTY720. OSU-2S shows anticancer activity .

HY-149916

A2AR-antagonist-1	Adenosine Receptor	Cancer
A2AR-antagonist-1 (compound 38) is an orally active adenosine A2A receptor (A2AR) antagonist (IC₅₀=29 nM). A2AR-antagonist-1 exhibits anti-tumor activity and mouse liver microsomal metabolic stability (t_1/2=86.1 min). A2AR-antagonist-1 is also a T cells activator, via inhibiting immunosuppressive molecules (LAG-3 and TIM-3) and enhancing effector molecules (GZMB, IFNG, and IL-2) .

Cyclic Peptide Library	85 compounds
Cyclic peptides are polypeptide chains taking cyclic ring structure, which exhibit diverse biological activities, such as antibacterial activity, immunosuppressive activity and anti-tumor activity. Cyclic peptides, with the features of good binding affinity, target selectivity and low toxicity, show great success as therapeutics. Multiple cyclic peptides are currently in clinical use, for examples, gramicidin and tyrocidine with bactericidal activity, cyclosporin A with immunosuppressive activity, and vancomycin with antibacterial activity. Furthermore, cyclic peptides usually have the sufficient size and a balanced conformational flexibility/rigidity for binding to flat protein-protein interaction (PPI) interfaces, which have potential to develop PPI drugs. MCE offers a unique collection of 85 cyclic peptides, all of which have good bioactivities. MCE Cyclic Peptide Library is a powerful tool for drug discovery and PPI inhibitor screening.

Cyclosporin B	Peptides	Inflammation/Immunology
Cyclosporin B is a group of nonpolar cyclic oligopeptides with immunosuppressive activity. Cyclosporin B is used for the prevention of graft rejection in organ transplantation .

Cyclolinopeptide B	Peptides	Inflammation/Immunology
Cyclolinopeptide B is a cyclic nonapeptide with immunosuppressive activity on human peripheral blood lymphocytes .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W012352

2-Hydroxyanthraquinone	Quinones Monophenols Classification of Application Fields Anthraquinones Source classification Morinda umbellata Rubiaceae Phenols Plants Disease Research Fields Cancer	Others
2-Hydroxyanthraquinone, a natural compound, possesses antitumor and immunosuppressive activity .

HY-N4319

Jasminoside B	Triterpenes Classification of Application Fields Terpenoids Source classification Rubiaceae Plants Gardenia jasminoides Ellis Disease Research Fields Inflammation/Immunology	Others
Jasminoside B is a natural compound with immunosuppressive activity .

HY-N10238

Mycestericin G	Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease Research Fields Inflammation/Immunology	Endogenous Metabolite
Mycestericin G is a sphingosine-like fungal metabolite that exhibits immunosuppressive activity .

HY-N12739

Sibiriquinone A	Plantaginaceae Structural Classification Terpenoids Source classification Diterpenoids Veronicastrum sibiricum (L.) Pennell Plants	Others
Sibiriquinone A is a diterpene with immunosuppressive activity that can be isolated from the aerial parts of Veronicastrum sibiricum. Sibiriquinone A .